Yemen’s Houthi rebels are stepping up their missile attacks, keeping up what could be the last major front in the Middle East wars.

The US military on Tuesday said it hit targets in Yemen targeting the Houthi militia, hours after the Iran-backed group launched attacks on Israel. The United States Central Command (CENTCOM) said its warships and aircraft attacked a number of Houthi-linked sites,

Israel launched a multi-wave attack across Yemen in retaliation for Houthi missile and drone strikes, the Israeli military confirmed Thursday.

Israel is signaling a wider campaign against Houthi militants in Yemen, a mountainous and impoverished country more than 1,000 miles from Israeli territory.

Israel’s military says it intercepted a missile fired toward the country by Yemen’s Houthi rebels. The attack set off sirens late Monday in central areas of Israel, including Tel Aviv.

Tens of thousands of protesters took to the streets of Sanaa on Friday as part of a weekly demonstration in solidarity with Palestinians in the Gaza Strip. Those gathered waved flags, banners and rifles aloft as they chanted anti-American and anti-Israeli slogans.