The Detroit Lions lost for the first time since Sept. 15 in a high-scoring affair with the Buffalo Bills in Week 15 at Ford Field in Detroit in a matchup of two of the NFL's best teams. The Lions (12-1) fell into an early two-touchdown hole and could not ...

Winning 11 straight games in the NFL — the Detroit Lions’ current streak — is pretty rare. But winning 12 straight, as the Lions could do on Sunday with a victory over the Buffalo Bills at Ford Field (4:25 p.m., CBS)? That’s elite territory ...

Detroit — The Buffalo Bills defeated the Detroit Lions 48-42 Sunday at Ford Field in Detroit. This game was an offensive battle from start to finish. The teams combined for 1088 yards of offense ...

The Bills improved to 11-3, two games behind the Kansas City Chiefs in the AFC with three games remaining, and took a one-game lead over Pittsburgh for the conference’s second seed.

but he’s a powerful edge-setter against the run and the Lions must make the Bills one-dimensional on offense by stopping James Cook and the running game. Buffalo averages 6.47 yards per carry ...

Kickoff is on Sunday, Dec. 15, at 4:25 p.m. ET on CBS. The Detroit Lions will host the Buffalo Bills at Ford Field for a highly anticipated game.

Here’s the preview, odds, best bets, and expert predictions for the upcoming Buffalo Bills vs. Detroit Lions game.

The Detroit Lions are tied for the best record in the NFC, but can earn the No. 1 seed and a first-round bye by winning their final 3 games.

The Buffalo Bills jumped out to a 14-0 lead and outlasted the Detroit Lions at Ford Field in Detroit on Sunday, winning 48-42 in a matchup of two of the NFL’s top teams. The loss snapped the Lions’ 11-game winning streak. Buffalo’s Josh Allen threw for two touchdowns and ran for two more.

In a game featuring the two highest scoring offenses in the NFL, Sunday's game between the Buffalo Bills and Detroit Lions lived up to the hype.